| TESTICULAR DAMAGE CAUSES AND CHARACTERIZATION |
| Paper ID : 1084-ISCH |
| Authors |
|
Khaled Hesham Abdullah *1, Ahmed Said Alazzouni2, Basma Nasr3, Sherif Rabea Mohamed4, Aya Samir Fathalla4 1Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt 2Department of zoology, faculty of science, Helwan university, Cairo, Egypt. 3Faculty of science, Helwan University 4Lecturer |
| Abstract |
| Testicular damage refers to pathological alterations in the testicular structure, often leading to impaired spermatogenesis and hormonal dysfunction. This review explores the major causes and histopathological features of testicular damage, which can result from environmental toxins, infections, trauma, and systemic diseases. Environmental toxins, such as heavy metals and pesticides, lead to oxidative stress and cellular damage within the testes. Infections, particularly viral agents like mumps, HIV, and syphilis, cause inflammation and tissue destruction. Trauma-related injuries and physical damage result in vascular disruption, hemorrhage, and necrosis of germinal epithelium. Histological features commonly associated with testicular damage include germ cell apoptosis, tubular atrophy, interstitial fibrosis, and vascular congestion. Systemic diseases, such as diabetes, contribute to testicular dysfunction through microvascular injury and chronic oxidative stress. A comprehensive understanding of these histopathological changes is crucial for diagnosing testicular damage and identifying targeted therapeutic interventions. Addressing the underlying causes may help mitigate the long-term reproductive and hormonal consequences of testicular damage. |
| Keywords |
| Testicular Damage , Germ Cell Apoptosis ,Tubular Atrophy ,Interstitial Fibrosis . |
| Status: Abstract Accepted (Poster Presentation) |